I'm being swayed to the Dark Side of the Force... er, that is, e-readers.
A few months ago I nearly disowned my mother for owning a Kindle. Last week I found out my best friend ONLY reads on her e-reader now. I've been as resistant to change as Anakin Skywalker. I vowed I would only get a fancy gizmo one day if I was travelling a lot, it would help me keep up with my work, and I could download documents to it to read manuscripts on the go.
Thanks to a tip on Twitter (more gray than dark on the scale of evilness), I found out that I could download manuscripts to my (mom's) Kindle! I figured it out, thanks to Google, and spent all day on my couch reading, without being weighed down by my laptop. Who knew it was super comfy to read Kindle on the couch? Makes Snuggies obsolete too, you can hold and control the pages without freeing your hands from the blanket.
While I will still refuse to buy a book (unless I go on an extended trip) for the Kindle, preferring to buy it or borrow it, I'm not super anti-Kindle anymore. However, I really don't need an e-reader that can read my mind or tie my shoes, so don't expect me to have anything super fancy if you see me on the street (or conference).
So, be nice to the agents you are querying. Make sure your file is compatible to sending to those handy E-Readers (word or rtf or lol or wtf... ok, so I don't actually know them all). How else are e-readers going to change our world? Not just the world of readers either, but of how the behind-the-scenes people (agents, editors, etc) conduct business?